Kitty, Daisy & Lewis is a three-piece band comprising the siblings of the Durham family. Their music is influenced heavily by R&B, swing, jump blues, country and Western, blues, Hawaiian and rock 'n' roll. They are all multi-instrumentalists playing guitar, piano, banjo, lapsteel guitar, harmonica, double bass, ukulele, drums, trombone, xylophone and accordion between them. Kitty Daisy & Lewis were one of the opening acts in North America for Coldplay's Viva La Vida Tour.

They have supported artists such as Jools Holland, Mika, Billy Bragg, Mark Ronson and Razorlight at London's Earls Court Arena.
They also played the main stage at Bestival in 2006, 2007, 2008 and 2009 as well as playing twice at Glastonbury in 2007 and 2008. They have featured in Vogue and performed on Blue Peter. The band also featured in the 2008 documentary We Dreamed America about the influence of American roots music on British musicians.